Synthesis, Physico-chemical and Spectral Studies of Mercury Complex of Glimepiride, An Oral Antidiabetic Drug

Sibi Jose¹ and George Jacob²

¹Department of Chemistry, Sadhu Vaswani College, Bairagarh, Bhopal - 462 001, India.

²Blyth Academy, Department of Science, Lawrence Park, 3284, Toronto, Ontario, Canada.

Corresponding Author E-mail: iqbalospc@yahoo.com

DOI : http://dx.doi.org/10.13005/ojc/290225

ABSTRACT:

Glimepiride is a current, potent hypoglycemic agent used in NIDDM (Non-Insulin Dependent Diabetes Mellitus). Metal complex of glimepiride has been synthesized by reaction with mercury (II) in the form of its chloride. The conductometric titration using mono variation method indicates that complex is non-ionic and ML2 type with was further confirmed by Job’s method of continuous variation as modified by Turner and Anderson. Analytical data agrees with the molecular formula  (C24H34N4O5S) 2Hg . Structure of the complex was assigned as tetrahedral in which ligand molecules lies horizontally joining the central mercury atom. Infrared spectral and molar conductance data confirm the co-ordination of sulphonyl oxygen on one side and enolic oxygen attached from other side with the metal ion. Structure assigned to the complex is supported by analytical data and IR and NMR spectral data.

KEYWORDS:

Synthesis; antidiabetics; glibenclamide; IR spectra; NMR spectra

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Copy the following to cite this article: Jose S, Jacob G. Synthesis, Physico-chemical and Spectral Studies of Mercury Complex of Glimepiride, An Oral Antidiabetic Drug. Orient J Chem 2013;29(2).

Copy the following to cite this URL: Jose S, Jacob G. Synthesis, Physico-chemical and Spectral Studies of Mercury Complex of Glimepiride, An Oral Antidiabetic Drug. Orient J Chem 2013;29(2). Available from: http://www.orientjchem.org/?p=22163