Synthesis and Evaluation of New Substituted Pyrazoline Derivatives as Biological Agents

 Mahesh D. Bhanushali^1* and Shiva kumarm Hipparagi²

¹Department of Pharmaceutical Chemistry, Research Scholar, Bhagwant University, Ajmer, Maratha Mandal’s College of Pharmacy, Belgaum - 590 016, India.

²Department of Pharmaceutical Chemistry, KLE University's, College of Pharmacy, Rajajinagar, Bangalore - 40, India.

Corresponding Author E-mail: pc_mahe@yahoo.co.in

DOI : http://dx.doi.org/10.13005/ojc/290222

ABSTRACT:

Twelve new 3-(4-substituted benzyl)-5-(4-substituted phenyl)-1-phenyl-4, 5-dihydro-1H-pyrazole derivatives were synthesized by reacting 1-(4-substituted phenyl)-4-(4 substituted phenyl) but-3-en-2-one and phenyl hydrazine in ethanol. 1-(4-substituted phenyl)-4-(4 substituted phenyl) but-3-en-2-one were synthesized by condensation of substituted phenylacetone and substituted benzaldehyde in NaOH solution. The synthesized compounds were confirmed by spectra data. The compounds were evaluated in-vitro for their antibacterial, antifungal, anti-tubercular activity and in-vivo for their anti-inflammatory activity. Compounds P25, P29, P31 and P32 were found to exhibit good antimicrobial and anti-inflammatory activity.

KEYWORDS:

Pyrazoline; Antibacterial; Antifungal; Anti-tubercular; Anti-inflammatory activity

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Copy the following to cite this article: Bhanushali M. D, Hipparagi S. K. Synthesis and Evaluation of New Substituted Pyrazoline Derivatives as Biological Agents. Orient J Chem 2013;29(2).

Copy the following to cite this URL: Bhanushali M. D, Hipparagi S. K. Synthesis and Evaluation of New Substituted Pyrazoline Derivatives as Biological Agents. Orient J Chem 2013;29(2). Orient J Chem 2013;29(2). Available from: http://www.orientjchem.org/?p=22155