Synthesis and Evaluation of pH and Salinity-Sensitive Superabsorbent Hydrogel Based on Starch-g-poly (MAA-co-HEMA) as Oral Drug Delivery Systems

Mohammad Sadeghi¹* and Mojgan Yarahmadi²

¹Department of Chemistry, Science Faculty, Islamic Azad University, Arak Branch, Arak (Iran). ²Department of English, Humaniti Faculty, Islamic Azad University, Arak Branch, Arak (Iran).

ABSTRACT:

In this work, my purpose was to produce intelligent starch-based superabsorbent polymers to be used as carriers for the controlled delivery of cis-platin loaded drug. Mechanisms for hydrogel formation was proposed and the structure of the product was established using Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The effects of pH, ionic strength and levels of loaded drug on drug release profile in various surrounding media were investigated. The synthesized hydrogels were subjected to equilibrium swelling studies in simulated gastric and intestinal fluids (SGF and SIF). The loading drug yield was found to depend on both the impregnation time and the amount of encapsulated drug. In addition, the release of cis-platin from this kind of hydrogel was studied. In vitro drug-release studies in different buffer solutions showed that the most important parameter affecting the drug-release behavior of hydrogels is the pH of the solution. The release rate of cis-platin from hydrogel at pH 7.4 was faster than that at pH 1.2 due to the shrinkage of the hydrogel at pH 1.2.

KEYWORDS:

Starch; Hydrogel; Cis-platin; Drug delivery; Vinylic monomers

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Copy the following to cite this article: Sadeghi M, Yarahmadi M. Synthesis and Evaluation of pH and Salinity-Sensitive Superabsorbent Hydrogel Based on Starch-g-poly (MAA-co-HEMA) as Oral Drug Delivery Systems. Orient J Chem 2011;27(3).

Copy the following to cite this URL: Sadeghi M, Yarahmadi M. Synthesis and Evaluation of pH and Salinity-Sensitive Superabsorbent Hydrogel Based on Starch-g-poly (MAA-co-HEMA) as Oral Drug Delivery Systems. Available from: http://www.orientjchem.org/?p=11739