Synthesis and Reactions of 2,3-Dihydro (5h) 5-Aryl-7- Thiazolo(3,2-a)-Pyrlmidine-3-One. Derivatives of Potential Antibacterial Activities

Mowafia A. Salama*, Hiyam H. A. Mousa and Monira A L-Shaikh

Girls College of Education, Scientific Department, El-Setten Street, Riyadh Kingdom of Saudi Arabia

ABSTRACT:

1,4-Dihydro-4-aryl-6-styryl pyrimidine-2-thiol derivatives (II) were prepared and reacted with chlortoacetic acid in fused sodium acetate and acetic anhydride mixture to give compounds (III). 2-Aryl-methylene-2,3-dihydro 5H-5-aryl-7-stryl-thiazole (3,2-a) pyrimidine-3-one derivatives (IV) were obtained via the condensation of (III) with aromatic aldehydes in acetic anhydride . Compounds (IV) were also obtained directly throgh reaction of (II) with chloroacetic acid and aromatic aldehydes. Coupling of (III) with aryldiazonium salts gave 2 -aryl-hydrazono-2,3 dihydro-5-H-5-aryl-7-styryl-tiazole (3-2-a) pyrimidine -3-one derivatives (V). Reaction of (II) with 2 or 3 bromopropanoic acid afforded 2,3-dihydro-2 -methyl -5H-5-aryl-7-styrl-thiazolo 3,2-a pyrimidine 3 -one derivatives (VI) and 2,3- dihydro -6H-6-aryl-8-styryl-1,3-thiazin (3,2-a) pyrimidine -4-ones respectively.

KEYWORDS:

Synthesis; Reactions; Potentiall; Antibacterial

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Copy the following to cite this article: Salama M. A, Mousa H. H. A, L-Shaikh M. A. Synthesis and Reactions of 2,3-Dihydro (5h) 5-Aryl-7- Thiazolo(3,2-a)-Pyrlmidine-3-One. Derivatives of Potential Antibacterial Activities. Orient J Chem 1991;7(4).

Copy the following to cite this URL: Salama M. A, Mousa H. H. A, L-Shaikh M. A. Synthesis and Reactions of 2,3-Dihydro (5h) 5-Aryl-7- Thiazolo(3,2-a)-Pyrlmidine-3-One. Derivatives of Potential Antibacterial Activities. Orient J Chem 1991;7(4). Available from: http://www.orientjchem.org/?p=39834