The Influence of Bromocriptine on Free Amino Acid Contents in he Rat Testis

K. E, H. El Tahir, A. M. Ageel And A. R. Abu-Jayyab

Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh-11451, Saudi Arabia.

ABSTRACT:

Chronic treatment of male rats with bromocriptine (B) 20 mg kg-1I. P. for 6 weeks significantly increased the concentration of free glutamic acid, glycine taurine and aspartic acid in the testis (P<0.01. n=8). Co-adminitration of sulpiride with B significantly suppressed B- induced increases in the 4 amino acids (aas) It was concluded that the stimulant effect of B was due to activation of dopamine D2 receptors. B-induced increase in the above (aas) may contribute to the reported beneficial actions of the compound observed in infertile males.

KEYWORDS:

Bromocriptine; Contents; Rat Testis

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Copy the following to cite this article: Tahir K. E. H. E, Ageel A. M, Abu-Jayyab A. R. The Influence of Bromocriptine on Free Amino Acid Contents in he Rat Testis. Orient J Chem 1988;4(1).

Copy the following to cite this URL: Tahir K. E. H. E, Ageel A. M, Abu-Jayyab A. R. The Influence of Bromocriptine on Free Amino Acid Contents in he Rat Testis. Orient J Chem 1988;4(1). Available from: http://www.orientjchem.org/?p=41908