Synthesis and Anti-inflammatory Activity of Some 3, 5-Diaryl-2-Pyrazoline Derivatives

Omneya M. Khalil and Hanan M. Refaat

Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562 (Egypt).

Correspondign Author E-mail: omneyafawzy@yahoo.com

ABSTRACT:

Eleven new 3-(4-bromophenyl)-5-(4-fluorophenyl)-2-pyrazoline derivatives 4-9 and 11-15 were synthesized by using 1-(4-bromophenyl)-3-(4-fluorophenyl) prop-2-en-1-one (3). The newly synthesized compounds were evaluated for anti-inflammatory activity against carrageenan edema in albino rats at a dose of 10 mg/kg. All the compounds of this series showed promising anti-inflammatory activity. The most active compound of this series, 7 was found to be most potent, which has shown higher percentage of inhibition of edema than the standard drug indomethacin.

KEYWORDS:

Synthesis; 3, 5-diaryl-2-pyrazolines; Anti-inflammatory activity

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Copy the following to cite this article: Khalil O. M, Refaat H. M. Synthesis and Anti-inflammatory Activity of Some 3, 5-Diaryl-2-Pyrazoline Derivatives. Orient J Chem 2011;27(4).

Copy the following to cite this URL: Khalil O. M, Refaat H. M. Synthesis and Anti-inflammatory Activity of Some 3, 5-Diaryl-2-Pyrazoline Derivatives. Orient J Chem 2011;27(4). Available from: http://www.orientjchem.org/?p=24207