Fabrication and Comparison of Electro-Spun Poly Hydroxy Butyrate Valrate Nanofiber and Normal film and its Cellular Study

Ali Majdi¹, Esmaeil Biazar² and Saeed Heidari K.³

¹Young Researchers Club, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran. ²Department of Chemistry, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran. ³Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshty University of Medical Sciences,Tehran Iran.

ABSTRACT:

Tissue engineering is defined as the designing and engineering of structures to rebuild and repair a body damaged tissue. Scaffolding Poly Hydroxy Butyrate Valrate (PHBV) has shown good biocompatibility and biodegradable properties. Nanofibers have improved the performance of biomaterials, and could be considered effective. One of the important methods for designing nanofiber scaffold is the electrospinnig method. In this study , PHBV nanofibers were well designed. The samples were evaluated by SEM, contact angle and finally, cell culture. The SEM images showed the size average of nanofibers as to be about 280 nm. Contact angle analysis showed 67 degree for nanofibers and 86 degree for normal films. Cellular investigations (USS cells) showed better adhesion and cell growth and proliferation of nanofiber surfaces than normal samples.

KEYWORDS:

PHBV; nanofiber; electrospinning; USSCs; cellular investigation

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Copy the following to cite this article: Majdi A, Biazar E, Heidari K. s. Fabrication and Comparison of Electro-Spun Poly Hydroxy Butyrate Valrate Nanofiber and Normal film and its Cellular Study. Orient J Chem 2011;27(2).

Copy the following to cite this URL: Majdi A, Biazar E, Heidari K. s. Fabrication and Comparison of Electro-Spun Poly Hydroxy Butyrate Valrate Nanofiber and Normal film and its Cellular Study. Orient J Chem 2011;27(2). Available from: http://www.orientjchem.org/?p=24873