New Spectrophotometric Methods for the Determination of Naratriptan Hydrochloride in Bulk and its Pharmaceutical Formulations

C. Ramesh¹, G. Nagarjuna Reddy², T. V. Narayana³, K. V. S. Prasaa Rao⁴ and B. Ganga Rao⁵

¹V.V.Pura Institute of Pharmaceutical Sciences, Bangalore (India).

²A.M.Reddy Memorial College of Pharmacy, Narasaraopet, Andhra Pradesh (India).

³Vikas Institute of Pharmaceutical Sciences, Rajahmundry, Andhra Pradesh (India).

⁴Rahul Institute of Pharmaceutical Sciences & Research, Chirala, A.P. (India).

⁵College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, A.P. (India).

ABSTRACT:

Three simple sensitive and reproducible visible spectrophotometric methods (A, B, and C) for the determination of Naratriptan hydrochloride (NTP) in bulk samples and pharmaceutical formulations are described. Method A is based on the formation of colored co-ordination complex with cobalt thiocyanate (CTC). Method B is based on the formation of colored species with citric acid - acetic anhydride (CiA-Ac2O). Method C based on the formation of colored molecular complex involving NTP and sodium nitroprusside (SNP) in the presence of hydroxylamine mono hydrochloride (HA). Regression analysis of Beer’s law plots showed good concentration ranges 5-35, 2-10 and 10-60 µg mL-1 for methods A, B and C respectively. The applicability of the methods was examined by analyzing tablets of NTP.

KEYWORDS:

Naratriptan hydrochloride; CiA-Ac2O; SNP; HA; CTC; Spectrophotometry

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Copy the following to cite this article: Ramesh C, Reddy G. N, Narayana T. V, Rao K. V. S. P, Rao B. G. New Spectrophotometric Methods for the Determination of Naratriptan Hydrochloride in Bulk and its Pharmaceutical Formulations. Orient J Chem 2011;27(1).

Copy the following to cite this URL: Ramesh C, Reddy G. N, Narayana T. V, Rao K. V. S. P, Rao B. G. New Spectrophotometric Methods for the Determination of Naratriptan Hydrochloride in Bulk and its Pharmaceutical Formulations. Orient J Chem 2011;27(1). Available from: http://www.orientjchem.org/?p=24868