Synthesis Characterization and Pharmacological Activity of Novel Thiazolidin – 4 one Analogues

M. K. Gireesha¹, M. Irfan Ali², N. Srinivasulu¹ and N. K. Sathish

¹Medicinal Chemistry Research Division, VL College of Pharmacy, Raichur - 584 103 (India). ²Department of Pharmaceutical Chemistry, SAC College of Pharmacy, BG Nagara - 571 1448 (India).

ABSTRACT:

A new series of 4-oxo-thiazolidines (3a1-3a6) were prepared by reacting Sulphadiazine with substituted aldehydes in alcohol medium in presence of strong base. The resulted Schiff’s base undergoes cyclization with mercapto acetic acid and mercapto succinic acid to yield 4-oxo-thiazolidines (3b1-3b6) The structure of the final synthesized compounds were confirmed by IR, 1H-NMR and MASS spectral technique. The title compounds were screened for their analgesic, anticonvulsant and antibacterial activities.

KEYWORDS:

4-oxo-thiazolidines; Schiff’s base; Analgesic activity; Anticonvulsant activity; Antimicrobial activity

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Copy the following to cite this article: Gireesha M. K, Ali M. I, Srinivasulu N, Sathish N. K. Synthesis Characterization and Pharmacological Activity of Novel Thiazolidin – 4 one Analogues. Orient J Chem 2010;26(3).

Copy the following to cite this URL: Gireesha M. K, Ali M. I, Srinivasulu N, Sathish N. K. Synthesis Characterization and Pharmacological Activity of Novel Thiazolidin – 4 one Analogues. Orient J Chem 2010;26(3). Available from: http://www.orientjchem.org/?p=24298