Synthesis of Hydroxy Propyloximino-1-Benzoyl- Indole-2-One Derivatives as Antibacterial and Antifungal Activities

Harcharan Lal¹, T. P. Aggarwal¹, V. P. Singh and Ashok Kumar²

¹Department of Chemistry K.G.K P.G College Moradabad (India). ²Medicinal Chemistry Division, Department of Pharmacology L.L.R.M. Medical College, Meerut - 25 004 (India).

1-Benzoyl indole-2,3-dione (1)1-Benzoyl-3-oximindole-2-one (2) 3-(2', 3'-Epoxypropyloximino)-1-benzoyl indole-2-one (3) 3-(3'-Substituted phenyl-2'-hydroxy propyloximino)-1- benzoyl indole-2-ones (4-8) 3-(3'-Substituted trizzolo-2'-hydroxy propyloximino-1-benzoyl indole-2-ones (9-10) have been synthesized in present study. All the developed congeners of cephalosporin acid evaluated for their antibacterial and antifungal activity. Compound 10 was found to possess potent bactericidal activity in comparison to clinically used chemotherapeutic agents viz. ampicillin; norfloxacin and fluconazole. The structure of all newly hydroxy propyloximino derivatives were confirmed on the basis of spectral and analytical data

Hydroxy propyloximino Derivatives; Antibacterial and Antimicrobial activities