Simultaneous UV Spectrophotometric Determination of Atorvastatin Calcium and Telmisartan in Tablet Dosage form

R. Vijayalakshmi, A. R. Magesh and M. D. Dhanaraju*

Research Laboratory, GIET School of Pharmacy, NH-5 Chaitanya Nagar, Rajahmundry - 533 294 (India).  

Two accurate, precise, sensitve and economical procedures for simultaneous estimation of atorvastatin calcium and telmisartan in tablet dosage forms have been developed. First method employs formation and solving of simultaneous equations using 219 nm and 257nm as two analytical wavelengths for both drugs in 0.1 N NaOH. The second method is Q- analysis based on measurement of absorptivity at 240nm (as isobestic point) and 257nm (lmax of ATV). Atorvastatin calcium and telmisartan at their respective lmax 257 nm and 219 nm and at 240 (isobestic point) shows linearity in a concentration range of 50-150 mcg/ml and 10-50 mcg/mL respectively. The recovery studies confirmed accuracy of the proposed methods and low values of standard deviation confirmed precision of the methods. The methods were validated as per ICH guidelines.

Atorvastatin calcium; telmisartan; simultaneous-equations method; Q-analysis