Synthesis and in vitro antiplasmodial evaluation of some isoquine analogues

Chandra Nath Saha¹ and Sanjib Bhattacharya²*

¹Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh - 786 004 (India).

²Bengal School of Technology (A College of Pharmacy), Delhi Road, Sugandha, Hooghly 712102 (India).

ABSTRACT:

Isoquine is the regioisomer of amodiaquine that can not form hepato and haematotoxic active metabolites by biotransformation unlike amodiaquine. In present investigation, five new isoquine analogues were synthesized by a two-step method, characterized by spectral analyses and subsequently evaluated in vitro against the chloroquine sensitive RKL-2 strain of Plasmodium falciparum by JSB staining method. All synthesized compounds demonstrated differential extent of antiplasmodial activity against the test parasites. However, no compound was found to exhibit better antiplasmodial profile as compared to chloroquine.

KEYWORDS:

Isoquine; antiplasmodial; RKL-2; Plasmodium falciparum; JSB staining

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Copy the following to cite this article: Saha C. N, Bhattacharya S. Synthesis and in vitro antiplasmodial evaluation of some isoquine analogues. Orient J Chem 2009;25(4).

Copy the following to cite this URL: Saha C. N, Bhattacharya S. Synthesis and in vitro antiplasmodial evaluation of some isoquine analogues. Orient J Chem 2009;25(4). Available from: http://www.orientjchem.org/?p=22714