Synthesis and antimicrobial activity of some novel chalcones and their related compounds

Mohit Kumar Kaithwal, Poonam Garg and Shamim Ahmad

Department of Chemistry, Bareilly College, Bareilly - 243 005 (India).

ABSTRACT:

A of chalcones have been prepared by Claisen-Schmidt condensation reaction between selected aldehyde and selected ketones. The synthesised chalcones are thiophen-2-aldehydeacetophenone (TAAP), furan-2-aldehydeacetophenone (FAAP), 2-hydroxynapthaldehyde acetophenone (HNAP), cinnamaldehydeacetophenone (CAAP), thiophen-2-aldehyde-2' hydroxy-4'methoxyacetophenone (TAHMAP), furan-2-aldehyde-2' hydroxy-4'methoxyacetophenone (FAHMAP), 2-hydroxynapth-aldehyde-2'-hydroxy-4'-methoxyacetophenone (HNHMAP), cinnam-aldehyde-2'-hydroxy-4'-methoxyacetophenone (CAHMAP), thiophen-2-aldehyde-3'-chloroacetophenone (TACAP), furan-2-aldehyde-3'-chloroacetophenone (FACAP),2-hydroxynapthaldehyde-3'-chloro-acetophenone (HNCAP), cinnamaldehyde-3'-chloroacetophenone (CACAP), The chalcones were converted into respective quinoxalines by treating them with bromine water and acetic acid and finally methanolic solution of tetramethylenediamine. All chalcones and quinoxalines have been characterised by melting point, elemental analyses and spectral studies. The antimicrobial activities of these compounds have also been studied.

KEYWORDS:

Chalcones; Quinoxalines; antimicrobial activity

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Copy the following to cite this article: Kaithwal M. K, Garg P, Ahmad S. Synthesis and antimicrobial activity of some novel chalcones and their related compounds. Orient J Chem 2009;25(4).

Copy the following to cite this URL: Kaithwal M. K, Garg P, Ahmad S. Synthesis and antimicrobial activity of some novel chalcones and their related compounds. Orient J Chem 2009;25(4). Available from: http://www.orientjchem.org/?p=22702