ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
     FacebookTwitterLinkedinMendeley

The Estimation of Eprosartan Mesylate in Pharmaceutical Dosage forms by RP-HPLC

V. Kiran Kumar1, N. Appala Raju2, Jvln Seshagiri Rao3 and T. Saty3

1Department of Pharmaceutical Chemistry, Sree Chaitanya Institute of Pharmaceutical Sciences, LMD.Colony, Karimnagar - 505 527 (India).

2Department of Pharmaceutical Chemistry, Sultan-Ul-Uloom College of Pharmacy, Mount Pleasant, Road# 3, Banjara Hills, Hyderabad - 500 034 (India).

3University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam (India).

Article Publishing History
Article Received on :
Article Accepted on :
Article Metrics
ABSTRACT:

A simple, precise, rapid and accurate reverse phase HPLC method developed for the estimation of Eprosartan mesylate in tablet dosage form. An Xterra KP18 150x4.6 mm, 5 μm partical size, with mobile phase consisting of acetonitrile and 0.03 M potassium dihydrogen phosphate (pH adjusted to 3.0±0.05 with orthophosphoric acid) in the ratio of 35:65 v/v was used. The flow rate was 1 ml/min and the effluents were monitored at 215 nm. The retention time was 5.549 min. The detector response was linear in the concentration of 1-25 mcg/ml. The respective linear regression equation being Y= 6669.355x+892.3405. The limit of detection and limit of quantification was 0.1 and 0.5 mcg/ml respectively. The percentage assay of Eprosartan mesylate was 99.77 %. The method was validated by determining its accuracy, precision and system suitability.The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which is useful for the routine determination of Eprosartan mesylate in bulk drug and in its pharmaceutical dosage form.

KEYWORDS:

Eprosartan mesylate; RP-HPLC; Estimation; and Tablets

Download this article as: 

Copy the following to cite this article:

Kumar V. K, Raju N. A, Rao J. S, Saty T. The Estimation of Eprosartan Mesylate in Pharmaceutical Dosage forms by RP-HPLC. Orient J Chem 2009;25(3).


Copy the following to cite this URL:

Kumar V. K, Raju N. A, Rao J. S, Saty T. The Estimation of Eprosartan Mesylate in Pharmaceutical Dosage forms by RP-HPLC. Orient J Chem 2009;25(3). Available from: http://www.orientjchem.org/?p=23111



Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.