Synthesis and Antibacterial Activity of Chalcones, Aminopyrimidines and Pyrazolines

Anjani Solankee*, Smruti Lad, Ghanshyam Patel and Sejal Solankee

Department of Chemistry, B.K.M.Science College,Valsad - 396 001 (India).

ABSTRACT:

Chalcones (E1-E5) have been prepared by the reaction between ketone (D) and different substituted aromatic aldehydes. These chalcones (E1-E5) were cyclized with guanidine nitrate and hydrazine hydrate to give aminopyrimidine (F1-F5) and pyrazoline (G1-G5) derivatives corresponding chalcones (E1-E5). The synthesized compounds were characterized by the spectral data and elemental analysis. These compounds were screened for their antibacterial activity by using ciprofloxacin as standard drug.

KEYWORDS:

Chalcones; aminopyrimidines; pyrazolines; spectral data; antibacterial activity

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Copy the following to cite this article: Solankee A, Lad S, Patel G, Solankee S. Synthesis and Antibacterial Activity of Chalcones, Aminopyrimidines and Pyrazolines. Orient J Chem 2009;25(1).

Copy the following to cite this URL: Solankee A, Lad S, Patel G, Solankee S. Synthesis and Antibacterial Activity of Chalcones, Aminopyrimidines and Pyrazolines. Orient J Chem 2009;25(1). Available from: http://www.orientjchem.org/?p=23361