An Efficient Synthesis of 4-Thiazolidinones Derivatives

Anjani Solankee*, Ghanshyam Patel and Sejal Solankee

Department of Chemistry, B.K.M. Science College, Valsad - 396 001 (India).

ABSTRACT:

2-(Substitutedphenyl/ 2-furanyl / 2""-thienyl)-3-(2'-ethylthiophene)-4-thiazolidinones (IIa-e) have been synthesized by cyclocondensation of thioglycolic acid with different Schiff-bases (Ia-e), which in turn were prepared by the action of different aromatic and heterocyclic aldehydes with thiophene-2-ethylamine. Cyclocondensation of Schiff-bases (Ia-e) with thiolactic acid resulted 2-(substitutedphenyl / 2""-furanyl / 2""-thienyl)-3-(2'-ethylthiophene)-5-methyl-4-thiazolidinones (IIa-e). The structure of newly synthesized compounds have been confirmed on the basis of IR, 1H NMR spectral data and physical data."

KEYWORDS:

Schiff-bases; thioglycolic acid; thiolactic acid; 4-thiazolidinones; spectral data

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Copy the following to cite this article: Solankee A, Patel G, Solankee S. An Efficient Synthesis of 4-Thiazolidinones Derivatives. Orient J Chem 2009;25(1).

Copy the following to cite this URL: Solankee A, Patel G, Solankee S. An Efficient Synthesis of 4-Thiazolidinones Derivatives. Orient J Chem 2009;25(1). Available from: http://www.orientjchem.org/?p=23423