Synthesis and Study of Antimicrobial Activity of Some New 3-(-Hydroxy-5-Methylphenyl)-4-Benzoyl-5-Phenylpyrazole

Neeta A. Junghare, Madhuri P. Bhise, M. M. chincholkar and P. R. Bhise

Department of Applied Science and Humanities, MCT's Rajiv Gandhi Institute of Technology, Andheri (W) Mumbai India.

Department of Chemistry, Government, Vidarbha Institute of Science and Humanities Amravati India.

Department of Microbiology, Dr. P.D.M. Medical College, Amravarti India.

ABSTRACT:

3-Aroyl-6-methyl flavones (Ia-f) were allowed to react with hydrozine hydrochloride in DMSO containing piperidine to give the corresponding 3-2-hydroxyphenyl-5-methyphenyl)-4-aroyl 5-arylpyrazoles (IIa-f) Their structural assignments are based on elemental analysis, spectral data (ir, uv and nmr) and chemical properties. All these compounds were tested in vitro for their antimicrobial (antibacterial and antifungal) activity by disk diffusion against gram positive, gram negative bacteria and fungi. In some of the compounds the results are found to be encouraging.

KEYWORDS:

3-(-Hydroxy-5-methylphenyl)-4-aroyl-5-arylpyrazole

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Copy the following to cite this article: Junghare N. A, Bhise M. P, Chincholkar M. M, Bhise P. R. Synthesis and Study of Antimicrobial Activity of Some New 3-(-Hydroxy-5-Methylphenyl)-4-Benzoyl-5-Phenylpyrazole. Orient J Chem 2008;24(2).

Copy the following to cite this URL: Junghare N. A, Bhise M. P, Chincholkar M. M, Bhise P. R. Synthesis and Study of Antimicrobial Activity of Some New 3-(-Hydroxy-5-Methylphenyl)-4-Benzoyl-5-Phenylpyrazole. Orient J Chem 2008;24(2).. Available from: http://www.orientjchem.org/?p=24414