Simultaneous Estimation of Ramipril and Valsartan in Pharmaceutical Dosage Form

Sohan S. Chitlange¹*, Mohammed Imran¹, Kiran Bagri² and Dinesh M. Sakarkar²

¹Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-18 India. ²S. N. Institute of Pharmacy, Pusad India.

ABSTRACT:

Simple spectrophotometric methods have been developed for simultaneous estimation of Ramipril (RAM) and Valsartan (VAL) in two component tablet formulation. The methods employed are Absorbance corrected for interference method and First order derivative spectroscopy method. For absorbance corrected for interference method the working wavelengths selected are 218 nm for RAM and 250 nm for VAL. Similarly for derivative spectroscopy method the working wavelength selected are 218 nm for RAM and 236 nm for VAL in 1:9 mixture of methanol and 0.1N HCl. For both the methods linearity was observed in the concentration range of 10-40 mg/ml for RAM and VAL. The recovery studies confirmed the accuracy of proposed method and the methods were validated as per ICH guidelines.

KEYWORDS:

Ramipril; Valsartan; Absorbance corrected for interference; Derivative spectroscopy

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Copy the following to cite this article: Chitlange S. S, Imran M, Bagri K, Sakarkar D. M. Simultaneous Estimation of Ramipril and Valsartan in Pharmaceutical Dosage Form. Orient J Chem 2008;24(1).

Copy the following to cite this URL: Chitlange S. S, Imran M, Bagri K, Sakarkar D. M. Simultaneous Estimation of Ramipril and Valsartan in Pharmaceutical Dosage Form. Orient J Chem 2008;24(1). Available from: http://www.orientjchem.org/?p=23283