Application of Uv-Spectrophotometry and First Order Derivative Methods for Determination of Telmisartan in Bulk and Tablets

N. R. Vekariya, R. A. Fursule*, A. A. Shirkhedkar and S. J. Surana

R. C. Patel College of Pharmacy, Karwand Naka, Shirpur- 425 405, Dhule India.

ABSTRACT:

Two simple, rapid, sensitive and accurate ‘UV- spectrophotometry’ and ‘first order derivative’ methods have been developed for estimation of telmisartan in bulk and tablets. 0.1M NaOH was used as solvent. In, ‘UV-spectrophotometry method’ absorbance of the samples was recorded at 295 nm. In ‘first order derivative method’, the amplitude of the troughs was recorded at 311 nm. In both the methods, telmisartan follows linearity in concentration range 2-18 µg/ml. In both the methods, assay results were in good agreement with label claim. These methods were validated statistically and recovery studies.

KEYWORDS:

Telmisartan; UV-Spectrophotometry; First order derivative

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Copy the following to cite this article: Vekariya N. R, Fursule R. A, Shirkhedkar A. A, Surana S. J. Application of Uv-Spectrophotometry and First Order Derivative Methods for Determination of Telmisartan in Bulk and Tablets. Orient J Chem 2008;24(1).

Copy the following to cite this URL: Vekariya N. R, Fursule R. A, Shirkhedkar A. A, Surana S. J. Application of Uv-Spectrophotometry and First Order Derivative Methods for Determination of Telmisartan in Bulk and Tablets. Orient J Chem 2008;24(1). Available from: http://www.orientjchem.org/?p=23339