Synthesis and Biological Evalutaion of 2-Amino-5- (Methyl-3-Benzoyl Benzyl - 1,3,4 - Oxadiazole Derivatives

Anshu Chaudhary*¹, Rupesh Dudhe² And Pradeep Singh¹

¹Shri Rammurty Smarak, College of Engineering and Technology, Ghanghora Ghangori, Bhojipuri, Bareilly - 243 202 (India) ²ZIM Laboratory M.I.D.C. Kalmeslwar Nagpur - 441 111 (India)

A new developed process for synthesis of 2-amino-5-(methyl-3-benzoyl benzyl)-1,3,4-oxadiazole derivatives(5a-e) have been synthesized from 2-(3-benzoyl phenyl) thiosemicarbazide propionic acid (3) and some derivatives of 2-amino-5-(methyl-3-benzoyl benzyl)-1,3,4 oxadiazole derivatives (5a-e) have been synthesized from 2(3-benzoyl phenyl)thiosemicarbazide propionic acid and tested for antibacterial, antifungal activities against for human pathogenic bacteria and fungi and anti-inflammatory activity on the albino rates. The structures of the synthesized compounds were elucidated by IR and ¹HNMR spectroscopic techniques. The antibacterial and antifungal screening of the synthesized compound were performed in vitro by the cup-plate diffusion method and the anti-inflammatory activity on albino rates were performed by carrageenan method.

Oxadiazole; anti-inflammatory; antibacterial; antifungal activity