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Microwave Assisted Synthesis of Some 2,5-Disubstituted 1,3,4-Oxadiazoles and Their Antimicrobial Activities

Volume 23, Number 2

Anurag Khatkar*, U.K. Singh, S.K. Dewan1 Jagbir Gagoria2 and Sarita3

1Dr. K.N.Modi Institute of Pharmaceutical Education and Research, Modi Nagar (India) 2Department of Chemistry, M.D.University, Rohtak (India) 3Institute of Pharmacy, Bndelkhand University, Jhansi (India) 3R.K.S.D. College of Pharmacy, Kaithal (India)

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ABSTRACT:

A variety of 2,5 – disubstituted 1,3,4 –oxadiazoles have been synthesized from Isoniazid and the corresponding aromatic acids both in the presence and in the absence of Mont morillonite K-10 clay catalyst. The synthesized compounds were screened for their antimicrobial activities. Better results were obtained in the presence of the catalysts.

KEYWORDS:

1;3;4-oxadiazole; microwave irradiation; antimicrobial activity

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Khatkar A, Singh U. K, Dewan S. K, Gagoria J, Sarita. Microwave Assisted Synthesis of Some 2,5-Disubstituted 1,3,4-Oxadiazoles and Their Antimicrobial Activities. Orient J Chem 2007;23(2).

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Khatkar A, Singh U. K, Dewan S. K, Gagoria J, Sarita. Microwave Assisted Synthesis of Some 2,5-Disubstituted 1,3,4-Oxadiazoles and Their Antimicrobial Activities. Orient J Chem 2007;23(2). Available from: http://www.orientjchem.org/?p=20174

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