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One-Pot Synthesis of 3,4-Dihydropyrimidones Catalysed by Mercury(Ii) Chloride: an Improved Procedure for Biginelli Reaction

Volume 23, Number 1

Mandaloju Neelanjana Rao and Chitneni Prasad Rao*

Department of Chemistry, Osmania University, Hyderabad - 500 007 (India)

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ABSTRACT:

An efficient method for the Biginelli reaction of aldehydes, ethyl acetoacetate and urea employing mercuric chloride as catalyst. These improved reaction conditions allow the synthesis of a wide variety of dihydropyrimidinones in excellent yields under mild reaction conditions with simple work up procedure.

KEYWORDS:

3;4-dihydropyrimidones; Mercury (II) chloride; Biginelli reaction

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Rao M. N, Rao C. P. One-Pot Synthesis of 3,4-Dihydropyrimidones Catalysed by Mercury(Ii) Chloride: an Improved Procedure for Biginelli Reaction. Orient J Chem 2007;23(1).

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Rao M. N, Rao C. P. One-Pot Synthesis of 3,4-Dihydropyrimidones Catalysed by Mercury(Ii) Chloride: an Improved Procedure for Biginelli Reaction. Orient J Chem 2007;23(1). Available from: http://www.orientjchem.org/?p=19876/a>

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