Synthesis and Characterization of Carboxamides of 2'-Amino-4'-(6-Chloro-3-Coumarinyl) Thiazole As Potential Nsaids
B. S. Jayashree1*, D. Anuradha2 and K. N. Venugopala1
1Department of Pharmaceutical Chemistry, Al-Ameen College of Pharmacy, Near Lalbagh Main Gate, Hosur Road, Bangalore - 560 027, Karnataka (India) 2Department of Pharmaceutical Chemistry, Kamala Nehru Polytechnic for women and Sarojini Naidu Pharmacy Maha Vidyalaya, Hyderabad (India)
A series of carboxamides of 2'-amino-4'-(6-chloro-3-coumarinyl) thiazole were synthesized, purified and characterized on the basis of spectral data such as IR, 1H-NMR and mass spectral (MS) studies and were evaluated for their analgesic and anti-inflammatory activity by acetic acid induced abdominal constriction method and carrageenan induced rat hind paw oedema method respectively. Out of the compounds tested, few test compounds showed significant analgesic and anti-inflammatory activity.
KEYWORDS:Carboxamides; aminothiazolyl coumarin; analgesic; anti-inflammatory activity
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| Copy the following to cite this article: Jayashree B. S, Anuradha D, Venugopala K. N. Synthesis and Characterization of Carboxamides of 2'-Amino-4'-(6-Chloro-3-Coumarinyl) Thiazole As Potential Nsaids. Orient J Chem 2006;22(3). |
| Copy the following to cite this URL: Jayashree B. S, Anuradha D, Venugopala K. N. Synthesis and Characterization of Carboxamides of 2'-Amino-4'-(6-Chloro-3-Coumarinyl) Thiazole As Potential Nsaids. Orient J Chem 2006;22(3). Available from: http://www.orientjchem.org/?p=19588 |
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