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Synthesis and Antimicrobial Activity of 7-Substituted-2-(3,5-Dimethyl-Pyrazol-1-Yl)-6-Fluoro-2,3dihydro-Benzothiazole

Volume 22, Number 3

S. M. Hipparagi et al.,

Department of Pharmaceutical Chemistry, K.L.E.S’s College of Pharmacy 2nd Block Rajaji Nagar, Bangalore - 560 010 (India)

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ABSTRACT:

We prepared 7-Substituted-6-fluorobenzothiazol-2-ylamine(K2) from 3-Chloro-4-fluorophenylamine. 7-substituted-6-fluorobenzothiazol-2-ylamine on treated with hydrazine hydrate to get 7-substituted-6-fluoro-benzothiazol-2-yl-hydrazine(K3) and than prepared 7-substituted-2-(3,5-dimethyl-pyrazol-1-yl)-6-fluoro-2,3-dihydrobenzothiazole(KS 1-9). Various compounds and their derivatives were prepared and confirmed by IR, NMR. Antimicrobial study shows that synthesized compounds have moderate activity.

KEYWORDS:

Benzothiazole; pyrazole; antimicrobial activity

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Hipparagi S. M. Synthesis and Antimicrobial Activity of 7-Substituted-2-(3,5-Dimethyl-Pyrazol-1-Yl)-6-Fluoro-2,3dihydro-Benzothiazole. Orient J Chem 2006;22(3).

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Hipparagi S. M. Synthesis and Antimicrobial Activity of 7-Substituted-2-(3,5-Dimethyl-Pyrazol-1-Yl)-6-Fluoro-2,3dihydro-Benzothiazole. Orient J Chem 2006;22(3). Available from: http://www.orientjchem.org/?p=19583

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