Thiazolidinyl and Azetidinyl Quinazolinones as potent antibacterial agents

Ashok Kumar¹*, L. B. Nikkam¹, Bhaskar SHetty¹, Chatrasal Singh Rajput² and Vikas Singh²

*¹Department of Pharmacology, LLRM Medical College, Meerut - 250 004 (India) ²Department of Chemistry, DN College, Meerut (India)

2 methyl 3 substituted aryl-quinazolin-4 (3H)-ones (2a-2i) were prepared by the fusion of 2 methyl Benzoxazinones and substituted aniline. Then bromine in glacial acetic acid reacts with (2a-2i)to give 2 bromomethyl-3-substitutedaryl-quinazolin-4(3H)-ones (3a-3i). Further on reaction with hydrazine hydrate in ethyl alcohol to give 2 hydrazine methyl-3-substituted aryl quinazolin-4-(3H)ones (4a-4i). Then (4a-4i) were reflexed with substituted benzaldehyde in absolute alcohol to give 2[substituted benzylidene hydrazino methyl]-3-substituted aryl-quinazolin-4-(3H)ones (5a-5r) and they were further reacted separately with thioglycolic acid and mono chloro acetyl chloride to obtain 2-[4'-oxo-2'-substitutedaryl-thiazolindinyl]-amino methyl-3-substituted aryl quinazolin-4-(3H) ones (6a-6r) and 2-[4'-oxo-2'-substitutedaryl azetidinyl]-aminomethyl-3-substituted aryl quinazolin-4-(3H) ones (7a-7r) respectively. Structure of all these newly synthesised compound were confirmed by their spectral and analytical data and the compounds were evaluated for their anti bacterial activity.

Thiazolidinyl quinazolinones; azetidineyl quinazolinones; antibacterial