Synthesis and Antimicrobial Activity of Novel Series of 2-Aroyl-6-Nitrobenzoyl Amino Acids and Peptides
Rajiv Dahiya* and Devender Pathak
Pharmaceutical Chemistry Department, Rajiv Academy for Pharmacy, Mathura - 281 001 (India)
Two novel series of 2-benzoyl-6-nitrobenzoic acid and 2-(4-chlorobenzoyl)-6-nitrobenzoic acid derivatives of amino acids, peptides and their methyl esters were synthesized by using DCC as coupling agent and TEA as base. All the synthesized compounds were characterized by IR, 1H NMR, 13C NMR and MS spectral data as well as elemental analysis and screened for antimicrobial activities. Compounds (1ii, 1iii and 2ii) were found to exhibit potent antibacterial activity against gram negative bacteria P. aeruginosa, E. coli and compounds (1ii, 2iii and 3ii) were found to be potent antifungal agents against pathogenic Candida albicans.
KEYWORDS:o-Aroylbenzoic acid; amino acids; dipeptides; antimicrobial activity
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| Copy the following to cite this article: Dahiya R, Pathak D. Synthesis and Antimicrobial Activity of Novel Series of 2-Aroyl-6-Nitrobenzoyl Amino Acids and Peptides. Orient J Chem 2006;22(1). |
| Copy the following to cite this URL: Dahiya R, Pathak D. Synthesis and Antimicrobial Activity of Novel Series of 2-Aroyl-6-Nitrobenzoyl Amino Acids and Peptides. Orient J Chem 2006;22(1). Available from: http://www.orientjchem.org/?p=19381 |
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