A Selective Rp-Hplc Method for the Determination of Pantoprazole in Pure form and in Pharmaceutical Dosage Form
D. Gowri Sankar*, M. S. M. Raju, S. Kalyan Sumanth and P. V. M. Latha
Department of Pharmaceutical Sciences, Andhra University Visakhapatnam- 530 003 (India)
A reverse phase high performance liquid chromatographic (HPLC) method has been developed for the estimation of pantoprazole in bulk form and in pharmaceutical formulations. The quantification was carried out using a RP C-18 column in isocratic mode, with mobile phase consisting of 0.1%. Triethyl amine and pH 2.8 Buffer solution (methanol and phosphoric acid) in the ratio of 32:68(v/v). Beclomethasone dipropionate was used as an internal standard. The detection was carried out at 289 nm and the linearity was found to be in the range of 3-15 μg/ml. The proposed method was found to be simple, precise, accurate, less time consuming and reproducible for the estimation of pantoprazole in pharmaceutical dosage forms i.e. tablets. The method was duly validated by evaluation of the required parameters.
KEYWORDS:HPLC; Pantoprazole; Pharmaceutical dosage forms
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| Copy the following to cite this article: Sankar D. G, Raju M. S. M, Sumanth S. K, Latha P. V. M. A Selective Rp-Hplc Method for the Determination of Pantoprazole in Pure form and in Pharmaceutical Dosage Form. Orient J Chem 2005;21(1). |
| Copy the following to cite this URL: Sankar D. G, Raju M. S. M, Sumanth S. K, Latha P. V. M. A Selective Rp-Hplc Method for the Determination of Pantoprazole in Pure form and in Pharmaceutical Dosage Form. Orient J Chem 2005;21(1). Available from: http://www.orientjchem.org/?p=18949 |
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