Synthesis and Antimicrobial Activity of Imidazole-Quinazoline

Hitesh D. Patel*, B. D. Mistry** and K. R. Desai

¹Department of Chemistry, South Gujarat University, Surat-295 001 (India) ²Department of Chemistry, B. K. M. Science College, Valsad- 396 001 (India) ³Department of Chemistry, St. Xavier's College, Ahmedabad- 380 009 (India)

Imidazole-Quinazoline derivatives VI(a-j) and VII(a-j) were prepared from 3-amino-2-(Substituted Phenyl)-4-oxo quinazoline when 4-phenyl methylene-2-(4'-nitro phenyl)-5-oxo-1, 3-oxazole reacted with 3-amino-2-(substituted phenyl)-4-oxo quinazoline in presence of POCl3 in pyridine gave derivatives VII(a-j) and if reacted with 4-(3',4',5'-Trimethoxy phenyl methylene)--(4'-nitro phenyl)-5-oxo-1-3-oxazole in same condition gave derivatives VII(a-j). These compounds were characterized on the basis of elemental and spectral analysis. All the newly synthesized compounds were tested for their anti-microbial activity.

Imidazole-Quinazoline derivatives