Antibacterial Study of 2-(P-Tolyl Sulfonamido)-3-(N-Arylthioureido Carbonyl) Pyridine Derivatives

N. B. Patel* and P. R. Bhagat

Department of Chemistry, South Gujarat University, Surat- 395 007 (India)

ABSTRACT:

2-(p-Tolyl sulfonamido)-3-(N-aryl thioureido carbonyl) pyridine derivatives (IV a-j) prepared by three steps. The preparation of 2-chloro-3-pyridine carbonyl chloride (II) from 2-chloro-3-pyridine carboxylic acid (I) in the first step, the second step was the preparation of amide (III a-j)j from (II) using aryl thiourea and the formation of third step (IV a-j) from (III a-j) by using p-Tolyl sulfonamide. The structures of new compounds have been established on the basis of elemental analysis, IR and 1H NMR spectral data. The antibacterial activity was screened for all the synthesized compounds.

KEYWORDS:

Pyridine derivatives; antibacterial activity; IR; 1H NMR spectra

Download this article as: 

Copy the following to cite this article: Patel N. B, Bhagat P. R. Antibacterial Study of 2-(P-Tolyl Sulfonamido)-3-(N-Arylthioureido Carbonyl) Pyridine Derivatives. Orient J Chem 2002;18(3).

Copy the following to cite this URL: Patel N. B, Bhagat P. R. Antibacterial Study of 2-(P-Tolyl Sulfonamido)-3-(N-Arylthioureido Carbonyl) Pyridine Derivatives. Orient J Chem 2002;18(3). Available from: http://www.orientjchem.org/?p=17518