Antibacterial and Antifungal Activity of Chalcones 3-Aroylflavanones, and 3-Aroylchromanones

S. R. Dighade^1#, S. D. Patil²*, M. M. Chincholkar³** and N. R. Dighade¹

¹Department of Chemistry, R.D.I.K. and N.K.D. Science College, Badnera- 444 701 ²Department of Microbiology, Shri Shivaji Science College, Amravati - 444 603 ** ³Department of Chemistry, Vidarbha Mahavidyalaya, Amravati- 444 603

Seven different chalcones I (a)-I (g) were synthesised by literature method from 2-hydroxy-5-methyl-acetophenone and tested for antibacterial activity against Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Bacillus megatherium and antifungal activity against Candida albicans, Candida guillermondii, Candida tropicalis and Candida crusei. Seven different 3-aroylflavanones and 3-aroyl-chromanones (IIa-IIg) were synthesised and tested for antibacterial and antifungal activity using above test organisms. Both chalcones and 3-aroylflavanones, 3-aroyl-chromanones showed antibacterial and antifungal activities. 3-aroylflavanones and 3-aroylchromanones were more effective than chalcones against fungal species. Both 3-aroyl-flavanones and 3-aroylchromanones exhibited highest antifungal spectrum against Candida crusei.

Antibacterial; antifungal activity of chalcones; 3-aroylflavanones; 3-aroylchromanones