Novel Synthesis and Antibacterial Activity of Some 4,5,6-Substituted-1,3-Thiazines

B. B. Wankhade¹*, M. M. Chincholkar²# and C. D. Khedkar³+

¹Department of Engineering Chemistry, B.N. College of Engineering, Pusad- 445 215 (India) ²Department of Chemistry, Government Vidarbha Mahavidyalaya, Amravati- 444 604 (India) ³Department of Microbiology, College of Dairy Technology, Warud- 445 204 (India)

Thiazines are reported to exhibit biological activity. In the present investigations some 3-aroyl flavanones (2a-d) and 2-furyl-3-aroylchromanones (2e-f) were subjected to react with thiourea in pyridine to form respective 5-aroyl-4,6-aryl subjected-1,3-thiazines (3a-f). Their structures were confirmed by chemical properties, elemental and spectral analysis. The compounds synthesized were screened for their antibacterial activity individually and in combination against some Gram +ve and Gram -ve organisms by using Kirby-Baur's disc diffusion method. It has been observed that thiazines showed moderate antibacterial activity and indifference combined antibacterial activity against the test organisms at a concentration of 50μg compound per disc.

Substituted thiazines; Antibacterial activity