Synthesis of Solid-Phase Peptides using New Base Labile Protecting Group: 2(2,4-Dinitrophenylsulphonyl) Ethyloxy-Carbonyl Chloride

Jashree Gurnani, C. K. Narang and M. R. K. Sherwani

Department of Chemistry, J.N.V. University, Jodhpur - 342 005 India.

ABSTRACT:

Synthesis of (Gly-Gly-Gly, I); (Phe-Gly-Phe-Gly, II); (Thr-val-Leu, III); (Try-Gly-Gly-Phe-Leu, IV) and (Gly-Asp, V) has been carried out using 2(2,4-dinitrophenylsulphonyl) ethyloxycarbonyl group (DNPSO₂ EOC)-Protected amino acids, KR-C00516 resin (solid support) in dichloroethane/ DMF. The progress of the reaction was monitored chemically, chromatographically and spectrophotometricaily.

KEYWORDS:

dinitrophenylsulphonyl; ethyloxycarbonyl chromatographically

Download this article as: 

Copy the following to cite this article: Gurnani J, Narang C. K, Sherwani M. R. K. Synthesis of Solid-Phase Peptides using New Base Labile Protecting Group: 2(2,4-Dinitrophenylsulphonyl) Ethyloxy-Carbonyl Chloride. Orient J Chem 2000;16(3).

Copy the following to cite this URL: Gurnani J, Narang C. K, Sherwani M. R. K. Synthesis of Solid-Phase Peptides using New Base Labile Protecting Group: 2(2,4-Dinitrophenylsulphonyl) Ethyloxy-Carbonyl Chloride. Orient J Chem 2000;16(3). Available from: http://www.orientjchem.org/?p=36144