Synthesis and Pharmacological Studies of Some New 11H- Indolo[3,2-C] Isoquinolin-5-Ylthio)Acetyl Thiosemicarbazide Andits Derivatives

Anand R. Saundane, S. H. Ranganafh, G. Prayagraj, K. Rudresh and N. D. Satyanarayana

Department of Chemistry. Gulbarga University, Gulbarga 585 106, India.

ABSTRACT:

8-methyl 11H-indolo [3,2-c] isoquinolin -5-ylthio) acetyl thiosemicarbazide (II) was prepared by the reaction of 8-methyl-11 H-indolo[3,2-c] isoquinolin-5-yithio) acetic acid hydrazide (I) and ammonium thiocyanate. Acetyl thiosemicarbazide (II) was converted into 5-[(8-methyl 11H-indolo[3.2-c]isoquinolin- 5-ylthio) methyl)-2-amino-1,3.4-thiaiazole (III) and 5-[(8-methyhl 11H-indolo[3 2-c]isoquinolin-5-ylthio) methyl]-4H-1,2,4-triazole-3-thiol (IV) by cyciodehyciration with phosphoric actd and alkali cyclization at reflux conditions, respectively. Compound (IV) on reaction with ethytchloroacetate yielded ethyl 5-[(8- methyl 11H-indolo [3,2-c]isoquino-5-ylthio) methyl}-1,2.4-triazole-3-thio] acetate (V) .The structures of these compounds were confirmed by their spectral studies. All the unknown compounds were tested for their various pharmacological activities such as analgesic anti-inflammatory, antheimentic and antibacterial activities.

KEYWORDS:

Thiosemicarbazide; ylthio; methyl; cyciodehyciration isoquinolin

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Copy the following to cite this article: Saundane A. R, Ranganafh S. H, Prayagraj G, Rudresh K, Satyanarayana N. D. Synthesis and Pharmacological Studies of Some New 11H- Indolo[3,2-C] Isoquinolin-5-Ylthio)Acetyl Thiosemicarbazide Andits Derivatives. Orient J Chem 1998;14(2).

Copy the following to cite this URL: Saundane A. R, Ranganafh S. H, Prayagraj G, Rudresh K, Satyanarayana N. D. Synthesis and Pharmacological Studies of Some New 11H- Indolo[3,2-C] Isoquinolin-5-Ylthio)Acetyl Thiosemicarbazide Andits Derivatives. Orient J Chem 1998;14(2). Available from: http://www.orientjchem.org/?p=22094