Synthesis, Characterization and Microbial Activity of Naphthalene Containing 1,3-Thiazines

H.S. Patel and Nilesh P. Patel

Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388 120, India.

1.3 - Thiazine derivatives have been prepared in 60-80% yield by the reaction of various chalcones containing naphthalene moeity with thiourea or diphenyl thiourea in alkaline medium for 3-4 hrs. The same reaction in DMSO-sodium methoxide system was found to be fast and give better yield. These compounds were screened for antifungal and antibacterial activities to various test organisms.

1.3 - Thiazine; chalcones; naphthalene moeity; diphenyl thiourea