Synthesis and Antimicrobial Activities of New Pyrazolines and its Derivatives

A. W. Raut and A. G. Doshi

Department of Chemistry, Shri. Shivaji Science College, Morshi Road, Amravati - 444 602 (India)

ABSTRACT:

2-Hydroxy-3-bromo-5-chloro acetophenone(l) condenses with substituted benzaldehyde in DMF in presence of pulvarised KOH gives chalcone (lla-b). Chalcone (lla-b) reacts with hydrazine hydrate in ethanol gives pyrazoline (llla-b). Pyrazoline (llla-b) reacts with acetic acid gives 1-acetylpyrazoline (I Va-b). Pyrazoline (IIIa-b) reacts with benzoylchloride in pyridine medium gives 1-benzoyl pyrazoline (V a-b). The structure were established on tie basis of spectral data UV, IR and PMR. Antimicrobial activities of these compounds were assayed against test organism Salmonella typhi, Salmonella paratyphi, Proteous vulgaris, Xanthomonas sppt Fusarium solznii and Botryties cinerea.

KEYWORDS:

Antimicrobia; Benzaldehyde; Organism

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Copy the following to cite this article: Raut A. W, Doshi A. G. Synthesis and Antimicrobial Activities of New Pyrazolines and its Derivatives. Orient J Chem 1995;12(1).

Copy the following to cite this URL: Raut A. W, Doshi A. G. Synthesis and Antimicrobial Activities of New Pyrazolines and its Derivatives. Orient J Chem 1995;12(1). Available from:http://www.orientjchem.org/?p=37686