Synthesis of Some New Ring 'A' Substituted Vasicine Analogues

R. L Sharma and Anil Prabhakar

Post Graduate Department of Chemistry, University of Jammu, Jammu-Tawi, 180 004 India

ABSTRACT:

Ten analogues of vasicine or 1,2,3,9-tetrahydropyrrolo (2,1-b) quinazoline-3-01(IV); 4-methoxy-(V);5- methoxy(VI)-; 6-methoxy-(VII)-; 4.6-dimethoxy-(VlII)-; 4,5,6,4trimethoxy-(IX)-; 4,5-methylenedioxy-(X)-; 5-hydroxy-4-methoxy(XI)-;6-hydroxy-5-methoxy-(XII)-;4-hydroxy-5-methoxy-(XIII) and 4,6-dibromo- (XIV)-vascines have been synthesised employing schopf-oechler scheme. The structures of the compounds have been established on the basis of spectral data. They have been screened for their pharmacological activities also.

KEYWORDS:

Substituted; Analogues; schopf-oechler

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Copy the following to cite this article: Sharma R. L, Prabhakar A. Synthesis of Some New Ring 'A' Substituted Vasicine Analogues. Orient J Chem 1994;10(1).

Copy the following to cite this URL: Sharma R. L, Prabhakar A. Synthesis of Some New Ring 'A' Substituted Vasicine Analogues. Orient J Chem 1994;10(1). Available from:http://www.orientjchem.org/?p=38161