Abstract

Shankaraiah Pagilla¹, Siddhartha Marupati¹ and Kishore Nani²

DOI : http://dx.doi.org/10.13005/ojc/330645

Suzuki cross coupling reaction based synthetic method for the preparation of 6-aryl-quinazolin-4(3H)-ones (3a-h)  in ethylene glycol dimethyl ether is described by coupling of 6-iodo-2-phenyl-3-methyl-quinazolin-4(3H)-one (1) with various 6-aryl boranic acids 3 under microwave irradiation These compounds were screened for anti-oxidant activity.

6-iodoquinazolin-4(3H)-one, aryl boranic acid, Pd(PPh3)4, 1,1-diphenyl-2-picryl- hydrazil (DPPH), ABTS*+ (2, 2’-azino-bis (3-ethylben - zthiazoline- 6-sulphonic acid), Suzuki coupling, Ethylene glycol dimethyl ether, Microwave irradiation, Anti oxidant activity

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