Abstract

Shashank Sharma¹, S. K. Khanna², Jolly Singh³, Soami P. Satsangee^4*

DOI : http://dx.doi.org/10.13005/ojc/31.Special-Issue1.24

A sensitive electroanalytical method for determination of acetaminophen (ACT) in paracetamol tablet has been developed and validated. Cyclic voltammetry (CV) was used to study the electrochemical behaviour of paracetamol, while differential pulse voltammetry (DPV) was used to determine ACT. Screen printed carbon electrode was used for the analysis. Determination of all parameters in paracetamol tablet was performed in phosphate buffer (PBS) from pH 4.0 to 9.0. The effects of various factors, such as the scan rates, pH were discussed. For assay of ACT, method validation steps such as linearity, precision, accuracy, limit of detection, limit of quantification were performed.

Cyclic voltammetry; paracetamol; phosphate buffer

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