Infrared Absorption Studies on Some New Potential Antimicrobial Diazotization Product of 4-aryl-Thiosemicarbazides

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The infrared absorption spectra of 4-aryl-3-thiosemicarbazides & 5-arylamino-1,2,3,4-thiatriazoles have been studied and structural assignments of importance to these systems made or suggested. Important conclusions drawn from the spectral data are : there in no suggestion of any thiol-thione tautomerism for the solid 4-aryl-3-thiosemicarbazides and that the thione structure predominates for these substances and that the diazotization products of the 4-arylthiosemicrabazides yield, 1,2,34-thiatriazole rather than the isomeric open chain thiocarbamylazides. The C=S, -N-C=S and cyclic -N-N=N- configurational assignments are discussed compounds 5-p-tolyl and 5-o-anisyl amino-1,2,3,4-thiatriazoles have shown antifungal activity against two fungi.

IR spectra and antifungal activity of 5-p-tolyl/ and 5-o-anisylamino 1,2,3,4-thiatraziles