Synthesis, Screening and QSAR Studies of 2,4-Disubstituted 1,5-Benzodiazepine Derivatives

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New 2,4-disubstituted 1,5-benzodiazepine derivatives containing different functional groups have been synthesized and screened for their antibacterial activity. The 2,4-disubstituted 1,5-benzodiazepine derivatives were synthesized by reacting substituted chalcones synthesized using aldol condensation with o-phenylenediamine. QSAR studies of synthesized derivatives were performed. QSAR equation show that electronic and liphopholic parameters have good correlation with anti bacterial activity. Lead molecules, which are designed in accordance with QSAR equations, are exhibit improved antibacterial activity.      

1,5-benzodiazepine; QSAR; antibacterial; aldol condensation