Synthesis of Some New Substituted 6-(2′-Dibenzothienyl)- Pyridazines as Anti-Hypertensive Agents

A. M. Sh.-El-Sharief, Y. A. Mohamed, Y. A. Ammar And A. G. Mahmoud

Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr-City, Cairo Egypt.

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ABSTRACT:

4, 5-Dihydro-6-(2'-dibenzothienyl~3-(2H) pyridazinone (IIIa) was obtained as a main product in the reaction of B- (2'-dibenzothieny) propionic acid with hydrazine hydrate. Dehydrogenation of (IIIa) with bromine gave (IV) which on treatment with phosphorous oxychloride gave the chloro derivative (V). Interaction of (V) with amines gave (VI). The effect of diazomethane, isocyanate, isothiocyanates, peosphorous pentasulphide and o-chlorobenzeldchyde on (IlIa) was discussed.

KEYWORDS:

Substituted; Pyridazines