Synthesis of Some New 2,3 Pyridine Dicarboxamino Acid Derivatives and Studies of their Biological Properties

A. F. EI-Haddad, A. H. Bedair, N. M. Nassar and A. M. El-Naggar

Chemistry Department, Faculty of Science, Al-Azhar University, Nasr-City, Cairo Egypt.

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ABSTRACT:

The synthesis of different 2,3-pyridine dicarboxamino acids (II-XI), 2,3-pyridine-dicarbox-Gly OMe, HCI (XII), hydrazides (XIII, XIV), dipeplide methyl esters (XV-XVIII) and aminoacylamides (XIX-XXIII) are described. Coupling of quinolinic acid-3-methyl ester with amino acid methyl ester hydrochlorides in dioxane-Et3N medium using the dicyclohexylcarbodiimide (DCC method furnishes the desired nicotinic acid methyl ester -2-carbonyl-amino acid methyl esters (XXV-XXIX). Twelve of the synthesized 2,3-pyridine dicarboxamino acids (II -XI) and the hydrazides (XIII, XIV) were found to be active against a number of microorganisms. Compounds (III and IV) were reported to possess some analgesic properties.

KEYWORDS:

Pyridine; Biological; Properties