Synthesis and Biological Activity of Some New 1,2,3, Selena and – Thiadiazolo-Imidazolones

B. E. Bayoumy, A. A. Hataba and F. I. Zahran

Department of Chemistry, Faculty of Science, Zagazig University, Zagazig Egypt

Download this article as:

ABSTRACT:

2-Methyl (or phenyl) -4- Substituted benzlidene- oxa-zolin-5-one (I) was allowed to react with p-aniinoacetophenone to afford imidazolone derivatives (II) which further reacted with semi-carbazide to produce the corresponding semicarbazone (III). The later compound was then subjected to oxidative cyclization either by selenium dioxide or thionyl chloride to give selena and thiadiazoles (IV) and (V) respectively. The structure of the final compound was confirmed on the basis of elemental and spectral analysis. Some of the prepared compounds were screened in viiro for their antibacterial and antifungal activity.

KEYWORDS:

Biological; Thiadiazolo-Imidazolones