Effect of Organophosphate Pesticide Dimecron (Phosphamidon) on the Level of D.N A, R.N.A and Protein of Rat Brain

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Dimecron (Phosphamidon) (2 Chloro-2-diethyl carbamoy 1-Methyl Vinyl diroctby) pbnsphate) 5 mg Kg body weight was injected intraperitonealiy (i p) daily for 10 days. The dairy i p dose of Dimecron (Hindustan Ciba Geigy Ltd.) depleted the level of D N A i n all brain regions, whereas the level of R N A decreased in cerebral hemisphere and increased in rest of the brain parts. Increased level of Protein was observed in cerebral hemisphere while the level decreased in cerebellum and brain stem

Organophosphate; Pesticide