Behaviour of 5, 6-Diphenyl-4-Carbethoxy 2,3-Dihydropyridazin 3- one, Towards Some Different Nucleophiles

Amina. Afify,; A. A. El-Khamry; A.Y. Soliman; M. A. Saved; E. A. Kassab

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Behaviour of 5, 6-Diphenyl-4-Carbethoxy 2,3-Dihydropyridazin 3- one, Towards Some Different Nucleophiles

Amina. Afify, A. A. El-Khamry, A.Y. Soliman, M. A. Saved and E. A. Kassab

Department of Chemistry, Faculty of Science, Ain Shams University, Cairo Egypt.

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ABSTRACT:

The hithertounknown 4- carbethoxy-5,6-diphenyl-2,3-dihydropyridazin-3-one (II) has been synthesized via cyclisation of diethyl-∝ -benzoylhydrazone-benzil malonate (I), which has been prepared on condensation of benzil monohydrazone with diethyl malonate. (II) reacted with primary amines, as well as, secondary amines producing (lll)a-g and/or (IV)a & b respectively. With some different Grignard reagents as carbon nucleosphiles, (II) reacted affording (V)a & b. (II), also, underwent hydroxy methylation on its reaction with form aldehyoe to give (VI), while, under -went complete Mannich reaction with formaldehyde and secondary amines providing (Vll)a & b.

KEYWORDS:

Towards; Different; Nucleophiles