Synthesis and Antibacterial Activity of 1,4-Disubstituted 2-Azetidinone


Faiza Siddieg El-Shafle, Mervat Mustafa El-En Any
Department of Pharmaceutical Chemistry, College of Pharmacy King Saud University, Riyadh, Serndi Arabia

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ABSTRACT:

Synthesis of 1,4-disubstituted β-lactam has been accomplished by a Ketene-imine cycloaddition reaction. The effect of -OCH3 and -NO2 groups on the yield have been studied. Also the antibacterial activity of these compounds has been investigated.

KEYWORDS:

Antibacterial; Activity


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