Some Reactions With Coumarins Sulphonyl Chloride and their Antibacterial Activities

F. M. Aly, A. H. Bedair and R. K. M. EI-Assy

Department of Chemistry Faculty of Science, Al-Azhar University. Nasr-City, Cairo, Egypt.

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ABSTRACT:

Different coumarins sulphonyl hydrazide and their hydrazones (III), (V), (VI) and (VII) were prepared, 4-Methyl-7-hydroaycoumarin-6-sulphonamides (VIII), (IX), (X) and (XX) were also obtained. Reaction of the sulphonyl chloride (II) with p-acetyl-aminobenzenesulphonehydrazide and add hydrolysis of the product was presented. The antibacterial activity of most of the newly prepared compounds were also discussed.

KEYWORDS:

Coumarins; Sulphonyl; Antibacterial