Determination of the pKa of Some Triazole Derivatives by the Potentiometric Method in Dioxan-Water Mixtures

Download this article as: 

Stoichiometric protonation constants of some 3-alkyl(aryl)-4-(substituted benzylamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones derivatives were determined potentiometrically in 50% (v/v) dioxan-water mixtures at 25oC with an ionic strength of 0.10 M. The calculation of the stoichiometric protonation constants was carried out using a PKAS computer program. The effect of solvents composition on the stoichiometric protonation constants are discussed.

Potentiometric titration; protonation constants; solvent effect; triazoles