Synthesis and Antimicrobial Activity of 8-Substituted-7-Fluoro-Benzo[4,5]Thiazolo[2,3-C][1,2,4]Triazole

S. M.Hipparagi; U. K. Majumder; M. Vyavahare; P. Panpaliya; K. Soni; L. V. G. Nar

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Synthesis and Antimicrobial Activity of 8-Substituted-7-Fluoro-Benzo[4,5]Thiazolo[2,3-C][1,2,4]Triazole

S. M.Hipparagi¹, U. K. Majumder², M. Vyavahare¹*, P. Panpaliya³, K. Soni², and L. V. G. Nar⁴

¹Department of Pharmaceutical Chemistry, K.L.E.S’s College of Pharmacy, Rajajinagar, Bangalore - 560 010 (India) ²Pharmaceutical Technology Department, Jadhavpur University, Kolkata - 700 032 (India) ³Nargund College of pharmacy, Dattaraynagar, Bangalore-560085 (India) 4Department of Chemistry. K.L.E.S’s S. Nijalingappa college, IInd Block, Rajaji Nagar Bangalore - 560 010 (India)

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ABSTRACT:

We synthesized 7-substituted-6-fluoro-benzothiazol-2-ylamine(M2) from 3-Chloro-4-fluoro phenylamine. 7-substituted-6-fluoro- benzothiazol-2-ylamine on treatment with hydrazine hydrate gives 7-substituted-6-fluoro-benzothiazol-2-yl-hydrazine(M3). And than prepared 8-substituted-7-fluoro-benzo[4,5]thiazolo[2,3-c][1,2,4]triazole (MV1-5) by treating with triethyl orthoformate. The derivatives were synthesized by treating with various substituted aromatic amines. Antimicrobial study shows that synthesized compounds have moderate activity.

KEYWORDS:

Benzothiazole; triazole; antimicrobial activity