Synthesis and Evaluation of New Substituted Pyrazoline Derivatives as Biological Agents
1Department of Pharmaceutical Chemistry, Research Scholar, Bhagwant University, Ajmer, Maratha Mandal’s College of Pharmacy, Belgaum - 590 016, India.
2Department of Pharmaceutical Chemistry, KLE University's, College of Pharmacy, Rajajinagar, Bangalore - 40, India.
Corresponding Author E-mail: pc_mahe@yahoo.co.in
DOI : http://dx.doi.org/10.13005/ojc/290222
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Twelve new 3-(4-substituted benzyl)-5-(4-substituted phenyl)-1-phenyl-4, 5-dihydro-1H-pyrazole derivatives were synthesized by reacting 1-(4-substituted phenyl)-4-(4 substituted phenyl) but-3-en-2-one and phenyl hydrazine in ethanol. 1-(4-substituted phenyl)-4-(4 substituted phenyl) but-3-en-2-one were synthesized by condensation of substituted phenylacetone and substituted benzaldehyde in NaOH solution. The synthesized compounds were confirmed by spectra data. The compounds were evaluated in-vitro for their antibacterial, antifungal, anti-tubercular activity and in-vivo for their anti-inflammatory activity. Compounds P25, P29, P31 and P32 were found to exhibit good antimicrobial and anti-inflammatory activity.
KEYWORDS:Pyrazoline; Antibacterial; Antifungal; Anti-tubercular; Anti-inflammatory activity
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